All Studies
AALPHI
Adolescents and Adults Living with Perinatal HIV cohort
ACTT-EU/UK
Adaptive COVID-19 Treatment Trial in the EU & UK (ACTT-EU/UK) - A Multicenter, Adaptive, Randomised Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalised Adults
Add-Aspirin
A phase III double-blind, placebo-controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours
ANYSNAKES
Advancing Management of Systemic Envenoming by testing multiple Antivenoms
ARCHERY
A prospective observational study of artificial intelligence based radiotherapy treatment planning for cervical, head and neck and prostate cancer
ARREST
Adjunctive Rifampicin to Reduce Early mortality from STaphylococcus aureus bacteraemia: a multi-centre, randomised, blinded, placebo controlled trial
ARROW
Anti-retroviral research for Watoto
AXIS
A randomised trial of post-operative portal vein infusion of fluorouracil vs surgery alone for colorectal cancer, and of peri-operative radiotherapy vs no radiotherapy for rectal cancer
Bladder cancer: (2005) Adjuvant chemotherapy, systematic review and IPD meta-analysis
Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data
Bladder cancer: (2022) Adjuvant chemotherapy, systematic review and IPD meta-analysis
Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials
Bladder cancer: Neoadjuvant chemotherapy, systematic review and IPD meta-analysis
Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data
BLISTER
The bullous pemphigoid steroids and tetracyclines study
BLT
Big Lung Trial: A randomised trial to determine the value of cisplatin-based chemotherapy for all patients with non-small cell lung cancer
BO01
Two adjuvant chemotherapy regimens in the treatment of osteosarcoma
BO02
A randomised pilot study of two drug combinations in patients with osteosarcoma
BO03
A randomised trial of two-drug versus multi-drug chemotherapy in the treatment of operable osteosarcoma
BO04
A phase II study of cisplatin, ifosfamide and doxorubicin (PIA) chemotherapy in operable primary, axial skeletal and metastatic osteosarcoma
BO05
A phase II study of Adriamycin and cisplatin in spindle cell sarcoma of bone other than osteosarcoma
BO06
A randomised trial of chemotherapy with or without granulocyte colony stimulating factor (G-CSF) in operable osteosarcoma
BR01
Medical Research Council Study of Misonidazole in Conjunction with Radiotherapy for the Treatment of Malignant Gliomas (Astrocytomas) Grades III and IV
BR02
A Medical Research Council Study of Two Radiotherapy Dose Regimens for the Treatment of Adult Patients with Malignant Gliomas Grades III and IV
BR03
A study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytomas
BR04
Randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC 22845 randomised trial
BR05
A randomised trial of adjuvant chemotherapy in high grade malignant glioma
BR12
Temozolomide versus PCV chemotherapy in the treatment of recurrent malignant glioma
BR13
Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade glioma after stratification for genetic 1p loss: a phase III study. Intergroup Study (EORTC 22033-26033)
BR14
Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON Intergroup trial
BREATHER
Short-Cycle Therapy (SCT) (5 days on/2 days off) in young people with chronic HIV infection
BREATHER Plus
A randomised open label two-arm, 96 week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir based triple ART in virologically suppressed HIV infected adolescents aged 12 to 19 years of age in sub Saharan Africa
CALM
A randomised placebo controlled trial of a cholinesterase inhibitor in the management of agitation in dementia that is unresponsive to a psychological intervention
CAMS
Cannabis in multiple sclerosis: a randomised, double blind, placebo controlled trial
Cancer: Stem cell transplantation, systematic review and aggregate data meta-analysis
Autologous stem cell transplantation for malignancy: a systematic review of the literature
CANPOP
A randomised clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on post-operative pain
CANPOP Dose Finding
An open label study: would a single oral dose of a cannabis plant extract (Cannador) help to provide pain relief after surgery.
CAP
An open phase I trial of 13% cellulose acetate phthalate vaginal microbicide with randomisation to an observation control
CAP-IT
Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial
CASCADE
Concerted action on seroconversion to AIDS and death in Europe
CDIFF
An International Prospective Observational Study to Assess the Characteristics and Outcomes of Post-transplant Patients Treated for C. Difficile Infections
Cervical cancer: Chemoradiotherapy, systematic review and IPD meta-analysis
Concomitant chemoradiotherapy versus radiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data.
Cervical cancer: hydroxyurea and radiotherapy, systematic review and aggregate data meta-analysis
Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review
Cervical cancer: Neoadjuvant chemotherapy, systematic review and IPD meta-analysis
Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data
CHAP
Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children: a double-blind randomised placebo-controlled trial
CHAPAS-3
Children with HIV in Africa – Pharmacokinetics and adherence/acceptability of simple antiretroviral regimens
CHAPAS-4
Children with HIV in Africa – Pharmacokinetics and Acceptability of Simple second-line antiretroviral regimens
CHART (CH01)
A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy
CHART (CH02)
A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in head and neck cancer
CHER
Children with HIV early antiretroviral therapy
CHIPS
Collaborative HIV Paediatric Study
CHIPS+
Optimising the health of young people with HIV in their transition from paediatric to adult care
CHORUS
A large phase III multi-centre randomised trial to determine the impact of timing of surgery and chemotherapy in newly diagnosed patients with advanced epithelial ovarian, primary peritoneal or fallopian tube cancer
COIN, CR10
A three arm randomised controlled trial comparing either continuous chemotherapy plus cetuximab, or intermittent chemotherapy with standard continuous palliative combination chemotherapy with oxaliplatin and a fluoropyrimidine in first line treatment of metastatic colorectal cancer
COIN-B
A two-arm phase II randomised trial of intermittent chemotherapy plus continuous cetuximab and of intermittent chemotherapy plus intermittent cetuximab in first line treatment of patients with K-ras-normal (wild-type) metastatic colorectal cancer
Colorectal cancer: Anti-EGFR treatment, systematic review and aggregate data meta-analysis
Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis
CoroNerve
A collaborative initiative to describe the neurological features of COVID-19
COSSMaT
Developing a Core Outcome Set for trials in the treatment of severe malaria
COVAC1
A first-in-human clinical trial to assess the safety and immunogenicity of a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID 19
CR09/FOCUS 2
Drug treatment for bowel cancer: making the best choices when a milder treatment is needed
CUTHIVAC 001
A Phase I clinical trial to assess the safety and immunogenicity of three HIV GTU® MultiHIV DNA immunisations administered via the Intramuscular, Intradermal and Transcutaneous routes in healthy male and female volunteers.
CUTHIVAC002
A Phase I clinical trial to assess the safety and immunogenicity of HIV DNA-C CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteers.
CUTHIVTHER 001
A randomized phase I/II study to assess the safety and immunogenicity of the DNA-GTU vaccine administered by two novel methods compared to placebo in HIV-infected patients on antiretroviral therapy
DART
Development of AntiRetroviral Therapy in Africa - A randomised trial of monitoring practice and structured treatment interruptions in the management of antiretroviral therapy in adults with HIV infection in Africa
DOMINO
Donepezil and memantine in moderate to severe Alzheimer’s disease
DREAM
A Duel centre dose-Ranging trial of Emmelle (dextrin sulphate) gel in preparation for an African Microbicide trial
D3
A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old
DADSPORT
Duration of androgen suppression with post-operative radiotherapy (DADSPORT): A meta-analysis of aggregate data
EARNEST
Europe-Africa Research Network for Evaluation of Second-line Therapy
EASTR
Epidemiology and survival of transfusion recipients
EHVA P01
A phase I, prophylactic HIV vaccine trial to evaluate the safety and immunogenicity of HIV Clade C DREP alone and in combination with a Clade C ENV protein in healthy HIV-uninfected adults
EHVA T01 (European HIV Vaccine Alliance Therapeutic Trial 01)/ANRS VRI05
A Phase I/II randomised therapeutic HIV vaccine trial in individuals who started antiretrovirals during primary or chronic infection
EHVA T02 (European HIV Vaccine Alliance Therapeutic Trial 02)/ANRS VRI07
A Phase II randomised, placebo-controlled trial of vedolizumab with or without therapeutic HIV MVA vaccine in individuals who started antiretrovirals during primary or chronic infection
Endometrial cancer: Chemotherapy, systematic review and aggregate data meta-analysis
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma
EPPICC
European Pregnancy and Paediatric Infections Cohort Collaboration
EURAMOS-1
A randomised trial of the European and American Osteosarcoma Study group to optimize treatment strategies for resectable osteosarcoma based on the histological response to pre-operative chemotherapy
EuroVacc 03/ANRS vac20
A trial to compare the immune responses and safety of two versus three DNA HIV vaccine primes in combination regimens with a pox vector boost in healthy volunteers
EV01
Evaluation of the NYVAC C vaccine in HIV-negative individuals
EV02
A phase I trial to assess the safety of 4 ml DNA C (intramuscular [IM]), and the safety and immunogenicity of DNA C followed by NYVAC C (IM) in an open, randomised comparison to NYVAC C alone in healthy volunteers at low risk of human immunodeficiency virus (HIV) infection
FEAST
Fluid Expansion As Supportive Therapy in critically ill African children.
FLU 002 Plus
An International Observational Study to Characterize Adults with Influenza or Other Targeted Respiratory Viruses
FLU 003 Plus
An international observational study to characterise adults who are hospitalised with influenza or other targeted respiratory viruses
FLU IVIG
Anti-Influenza Hyperimmune Intravenous Immunoglobulin Clinical Outcome Study
FOCUS-3
A study to determine the feasibility of molecular selection of therapy using KRAS, BRAF and topo-1 in patients with metastatic or locally advanced colorectal cancer
FOCUS4
A molecularly-stratified randomised controlled trial programme for patients with advanced colorectal (bowel) cancer
FORTE
An open, randomised trial to evaluate the activity and tolerability of combinations of reverse transcriptase and protease inhibitors, including induction therapy, in individuals with HIV-1 infection and CD4 counts greater than 25 x 106/L
GASTRO
Gastroenteritis Aggressive Versus Slow Treatment for Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO Plan C versus slower rehydration.
GASTROSAM
Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial
GIN
Granulocytes in Neutropenia clinical study
Glioma: Chemotherapy, systematic review and IPD meta-analysis
Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials
HCQ-01
Evaluation of the efficacy of hydroxychloroquine in decreasing immune activation in asymptomatic HIV-infected patients
HIVDRD
UK HIV Drug Resistance Database
HLA-Epitope
Trial of HLA epitope matched platelet transfusion in aplastic anaemia and MDS patients
HCVAVERT
Partnership to cure hepatitis C virus (HCV) in mono- and HIV/HCV co-infected pregnant women and prevent VERTical HCV transmission.
H-PRIME
Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden
ICOX PB001
A two-centre, randomised, double-blinded phase I study to evaluate the safety and immunogenicity of 2 doses of candidate HIV-1 Clade A DN/A vaccine or placebo followed by a candidate HIV-1 Clade A MVA vaccine or placebo in healthy volunteers at low risk of HIV infections
ICON6
A double-blind, placebo-controlled, three arm randomised multi-centre GCIG trial of AZD2171 in patients with ovarian cancer
ICON7
Chemotherapy with or without bevacizumab for ovarian cancer, primary peritoneal cancer or fallopian tube cancer
ICON8
An international phase III randomised trial of dose fractionated chemotherapy compared to standard three weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer
ICON8B
A phase 3 randomised trial investigating the combination of dose-fractionated chemotherapy and bevacizumab compared to either strategy alone for the first-line treatment of women with newly diagnosed high-risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer
INCH
Induction chemotherapy and CHART in non-small cell lung cancer
INITIO
An open randomised trial to evaluate different therapeutic strategies of combination therapy for HIV-1 infection
ITAC
An International Multicenter, Adaptive, Randomized Double-Blind, Placebo-Controlled Trial of the Safety, Tolerability and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Hospitalized Patients at Onset of Clinical Progression of COVID-19
ICOS
An International Observational Study of Outpatients with SARS-CoV-2 Infection
KONCERT
A Kaletra ONCE daily Randomised Trial of the pharmacokinetics, safety and efficacy of twice-daily versus once-daily lopinavir/ritonavir tablets dosed by weight as part of combination antiretroviral therapy in HIV-1 infected children.
KD-CAAP
Kawasaki Disease Coronary Artery Aneurysm Prevention trial
Lablite
Optimising clinical care strategies and laboratory monitoring for cost-effective roll-out of antiretroviral therapy in Africa: the Lablite project
LATA
Long-Acting Treatment in Adolescents (LATA): A randomised, open-label, two-arm, 96 week trial in virologically suppressed HIV-1-positive adolescents aged 12-19 years of age in sub-Saharan Africa
Leg Ulcers: Bandage comparison, systematic review and IPD meta-analysis
Four-layer compression bandage compared with short stretch bandage for venous leg ulcers: A systematic review and meta-analysis of randomised controlled trials of individual patient data
LU09
Three versus six courses of etoposide, cyclophosphamide, methotrexate and voncristine versus six courses of etoposide and ifosfamide in small cell lung cancer
LU10
A phase II trial of alternating chemotherapy and radiotherapy in small cell lung cancer
LU11
A randomised trial of post-operative radiotherapy in non-small cell lung cancer
LU12
A randomised trial of 4-drug vs less intensive 2-drug chemotherapy in the palliative treatment of patients with non-small cell lung cancer and a poor prognosis
LU13
A randomised trial of palliative 2-fraction vs more intensive 13-fraction radiotherapy for patients with inoperable NSCLC and a good performance status
LU14
Adding GCSF (lenograstim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer
LU15
Adding GCSF (filgrastim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer
LU16
A randomised trial of oral etoposide vs intravenous multi-drug chemotherapy in the palliative treatment of patients with small cell lung cancer and a poor prognosis
LU17
A randomised trial of supportive treatment with or without immediate thoracic radiotherapy in the prevention and palliation of symptoms in patients with inoperable non-small cell lung cancer and minimal thoracic symptoms
LU18
A randomised controlled clinical trial of endobronchial treatment versus external beam radiotherapy in the management of endotracheal or endobronchial obstruction by lung cancer
LU19
A randomised controlled intensification clinical trial of chemotherapy with or without recombinant human granulocyte colony stimulating factor (G-CSF) in small-cell lung cancer
LU20
A randomised trial of neo-adjuvant chemotherapy followed by resection versus radiotherapy in patients with T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer (NSCLC)
LU21
A randomised clinical trial of isosfamide, carboplatin and etoposide with mid-cycle vincristine (ICE-V) versus standard practice chemotherapy in patient with small-cell lung cancer (SCLC) and good performance status
LU22
Surgical resection with or without pre-operative chemotherapy in patients with operable non-small cell lung cancer
Lung cancer: preoperative chemotherapy, systematic review and IPD meta-analysis
Preoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant data
Lung cancer: chemotherapy, surgery, radiotherapy, two systematic reviews and IPD meta-analyses
Adjuvant chemotherapy and surgery (with or without radiotherapy) versus surgery (with or without radiotherapy) for non-small cell lung cancer: Two systematic reviews and meta-analyses of individual patient data
Lung cancer: chemotherapy and supportive care, a systematic review and IPD meta-analysis
Chemotherapy and supportive care versus supportive care for advanced non-small cell lung cancer: A systematic review and meta-analysis of individual patient data
Lung cancer: TKI inhibitors, systematic review and aggregate data meta-analysis
Should tyrosine kinase inhibitors be considered for advanced non-small cell lung cancer with wild type EGFR? Two systematic reviews and meta-analyses of randomised trials
Lung cancer: post-operative radiotherapy, a systematic review and IPD meta-analysis
Postoperative radiotherapy for non‐small cell lung cancer
LY06
A multicentre evaluation of National Cancer Institute protocol 89-C-41 (with minor modifications) in Burkitt or Burkitt-like non-Hodgkin lymphoma
LY09
A randomised trial of therapy for advanced Hodgkin lymphoma
MAVMET
A multicentre, 48 week randomised controlled factorial trial of adding maraviroc and/or metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapy.
MDP301
A phase III trial to test the effectiveness of PRO2000/5
MESO-1
A randomised trial of active symptom control with or without chemotherapy in patients with malignant pleural mesothelioma
MIA 001
A randomised, vaginal microbicide trial to assess the safety of dextrin sulphate gel versus vehicle placebo in Uganda
MIA 002
A randomised, placebo controlled, vaginal microbicide trial assessing the safety of PRO 2000/5 Gel (P) versus vehicle placebo in Uganda
MIST1
A randomised, double blind, placebo controlled study to assess the efficacy and safety of intra-pleural streptokinase in pleural empyema
MIST2
Second Multi-centre Intra-pleural Sepsis Trial
MOSAIC
Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular trial
Mucovac2
A Phase I clinical trial to assess the safety and immunogenicity of three HIV CN54gp140 immunisations administered through the intramuscular, intranasal and intravaginal routes in healthy female volunteers
N-ALIVE
Prison-based Naloxone-on-release pilot randomised controlled trial investigating the first 10% of a larger trial to reduce drugs-related deaths soon after release
NeoCHG
Efficacy and safety of whole-body chlorhexidine gluconate (CHG) cleansing in reducing bacterial skin colonisation of hospitalised neonates: A pilot trial
NeoSep1
An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase
Nix-TB
Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis
OCTOPUS
Optimal Clinical Trials Platform for Progressive Multiple Sclerosis
ODYSSEY (PENTA20)
A randomised trial of dolutegravir-based antiretroviral therapy vs. standard of care in children with HIV infection starting first-line or switching to second-line antiretroviral therapy.
OE02
Randomised controlled clinical trial of surgery with or without pre-operative chemotherapy in the treatment of respectable cancer of the oesophagus
OE05
A randomised controlled trial comparing standard chemotherapy followed by resection versus ECX chemotherapy followed by resection in patients with resectable adenocarcinoma of the oesophagus
Oesophageal cancer: Preoperative radiotherapy, a systematic review and IPD meta-analysis
Preoperative radiotherapy for oesophageal carcinoma: systematic review and meta-analysis of individual patient data
OV05
Early treatment based on CA125 levels alone versus delayed treatment based on conventional clinical indicators
OV07
Phase III study of Erlotinib vs. observation in ovarian cancer
PARADIGM4TB (UNITE4TB-01)
Platform Assessing Regimens And Durations In a Global Multisite consortium for TB: A seamless Phase 2B/2C platform trial to evaluate multiple regimens and durations of treatment in pulmonary tuberculosis)
PATCH (PR09)
A randomised controlled trial of transcutaneous oestrogen patches versus LHRH agonists in prostate cancer
PATCH I & II
Prophylactic Antibiotics for the Treatment of Cellulitis at Home
PCI
A randomised trial of prophylactic cranial irradiation in patients with limited disease SCLC and a complete response after induction therapy
PediCAP
Impact of oral step-down to amoxicillin or co-amoxiclav and of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in severe childhood community-acquired pneumonia (CAP): a randomised controlled trial
PedPolyB01
Can the dose of the polymyxin B antibiotic be optimised to be used in babies, children and adolescents?
PENPACT 1
A phase II/III randomised, open-label study of combination antiretroviral regimens and treatment-switching strategies in HIV-1 infected antiretroviral naïve children >30 days and <18 years of age.
PENTA 11
Treatment interruption in children with chronic HIV-infection
PENTA 15
Plasma pharmacokinetic study of once versus twice daily abacavir as part of combination antiretroviral therapy in children with human immunodeficiency virus-1 infection aged 3 months to <36 months
PERA / PENTA 8
A randomised trial to evaluate the usefulness of resistance testing in the clinical management of children with HIV infection.
PIVOT
Protease Inhibitor monotherapy Versus Ongoing Triple-therapy in the long-term management of HIV infection
PPIP
Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial
PR04
A randomised trial of oral sodium clodronate versus a matching placebo in patients with locally advanced prostatic adenocarcinoma
PR05
A randomised trial of oral sodium clodronate versus a matching placebo in patients with metastatic prostate adenocarcinoma.
PR06
Radical prostatectomy vs radical radiotherapy vs no immediate treatment for localised prostate cancer: a randomised controlled trial
PR07
A randomised trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer
PRE-MASTODON-AD
PREliminary development of a Multi-Arm, multi-Stage Trial platfOrm for Dementia & mild cOgNitive impairment due to Alzheimer's Disease (PRE-MASTODON-AD)
PREDICT
A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome
PrEPVacc
A Phase IIb three-arm, two-stage HIV prophylactic vaccine trial with a second randomisation to compare TAF/FTC to TDF/FTC as pre-exposure prophylaxis.
Prion disease: Systematic review
Systematic review of therapeutic interventions in human prion disease
PRION-1
Partially randomised trial of quinacrine in human prion disease
PRISM
Trial of Prion-filtered vs Standard Red cells in Surgical and Multi-transfused Patients
PROGRAMS
A multi-centre randomised controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor (GM-CSF) to reduce sepsis in pre-term infants
PROMIS
Prostate MRI Imaging Study - Evaluation of multi-parametric magnetic imaging in the diagnosis and characterisation of prostate cancer
PROUD
PRe-exposure Option for reducing HIV in the UK: an open-label randomisation to immediate or deferred daily Truvada for HIV negative gay men
RADICALS
Radiotherapy and androgen deprivation in combination after local surgery. A randomised controlled trial in prostate cancer
RAMPART
Renal Adjuvant MultiPle Arm Randomised Trial: An international investigator-led phase III multi arm multi stage multi-centre randomised controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse
RE04
A randomised controlled trial of Interferon-a, Interleukin-2 and 5-Fluorouracil vs Interferon-a alone in patients with advanced renal cell carcinoma
REALITY
Reduction of EArly mortaLITY in HIV-infected adults and children starting antiretroviral therapy
REFINE
REduced Frequency ImmuNE checkpoint inhibition in cancers
REMoX-TB
Controlled comparison of two moxifloxacin containing treatment shortening regimens in pulmonary tuberculosis
RIFAQUIN
An international multicentre controlled clinical trial to evaluate high dose rifapentine and a quinolone in the treatment of pulmonary tuberculosis
RIVER
Research In Viral Eradication of HIV Reservoirs
RT01
A randomised controlled trial of high dose versus standard dose conformal radiotherapy for localised prostate cancer
RID-TB: Treat
Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Treatment
RID-TB: Dx
Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Diagnostics
Sarcoma: adjuvant chemotherapy, systematic review and IPD meta-analysis
Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual participant data
SELPHI
SELPHI: An HIV Self-testing Public Health Intervention
SHIELD
A phase II double-blind, placebo controlled, randomised, single centre study to assess the safety, tolerability and acceptability of dextrin-2-sulphate (DS) gel in sexually active female subjects and their male sexual partners at low risk of HIV infection
SHINE
A randomised trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses/fixed-dose-combination drugs in African and Indian HIV+ and HIV- children
SimpliciTB
Evaluating the efficacy, safety and tolerability of a novel and potentially shorter drug regimen (BPaMZ) for patients with drug-sensitive (DS) and drug-resistant (MDR-) pulmonary tuberculosis
SMAART
Severe Malaria - A Research and Trials consortium
SMART
A large, simple trial comparing two strategies for management of anti-retroviral therapy
SMILE
Strategy for Maintenance of HIV suppression with once daily integrase inhibitor +darunavir/ritonavir in children
SNAP
Which standard of care antibiotic intervention is the most effective?
SORCE
A multi-centre phase III double-blind placebo-controlled study designed to examine the efficacy and tolerability of sorafenib (Nexavar) in patients with resected (total or partial) primary renal cell carcinoma (RCC) at high or intermediate risk of relapse
SPARTAC
Short Pulse Anti-Retroviral Therapy At sero-Conversion
ST02
A randomised, controlled trial of pre- and post-operative chemotherapy in patients with operable gastric and lower oesophageal cancer
ST03
A randomised phase II/III trial of perioperative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma and a feasibility study evaluating lapatinib in HER-2 positive oesophagogastric adenocarcinomas and (in selected centres) MRI and PET/CT sub-studies
STAMPEDE
Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy
STAND
Shorter Treatment for Advancing Novel Drugs
START
Strategic Timing of AntiRetroviral Treatment
STOP-HCV-1
Stratified Treatment Optimisation for HCV-1
STOPCAP M0, bisphosphonates, systematic review and aggregate data meta-analysis
Addition of bisphosphonates to standard of care in men with localised, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STOPCAP M0, docetaxel, systematic review and aggregate data meta-analysis
Addition of docetaxel to standard of care in men with localised hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STOPCAP M1 Programme
Speeding up the evaluation of therapies for metastatic, hormone-sensitive prostate cancer
STOPCAP M1, abiraterone, systematic review and aggregate data meta-analysis
Addition of abiraterone to standard of care in men with metastatic hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STOPCAP M1, aggregate data network meta-analysis
What is the optimal systemic treatment of men with metastatic, hormone-sensitive prostate cancer? a systematic review and network meta-analyses of aggregate data
STOPCAP M1, bisphosphonates, systematic review and aggregate data meta-analysis
Addition of bisphosphonates to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STOPCAP M1, docetaxel, systematic review and aggregate data meta-analysis
Addition of docetaxel to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STOPCAP M1, prostate RT, systematic review and aggregate data meta-analysis
Addition of prostate radiotherapy to ADT in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data
STREAM Stage 1
The evaluation of a standardised treatment regimen of anti-tuberculosis drugs for patients with MDR-TB
STREAM Stage 2
The Evaluation of a Standardised Treatment Regimen of Anti-Tuberculosis Drugs for Patients with MDR-TB
STRIVE
Strategies and Treatments for Respiratory Infections & Viral Emergencies
Study C
A randomised international multi-centre trial for the evaluation of a four-drug fixed dose combined tablet daily in the initial phase (2 months) of chemotherapy followed by a two-drug fixed dose combined tablet three times a week in the continuation phase (4 months) for the treatment of pulmonary tuberculosis.
SURE
A randomised trial of 6 months intensified anti-tuberculosis and 2 months anti-inflammatory treatment for HIV-infected and HIV-uninfected African and Asian children with tuberculous meningitis
SWET
Softened Water Eczema Trial
STAMPEDE2
Studying Treatments in patients receiving androgen deprivation therapy (ADT) and androgen receptor signalling inhibitors (ARSI) for Metastatic Prostate Cancer: Evaluation of Drug and radiation Efficacy: A 2nd multi-arm multi-stage randomised controlled trial (STAMPEDE2).
SNIP-AFRICA
Severe neonatal infection adaptive platform trials in Africa
TABS-PKPD
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children
Tamovac I
A Phase I/II trial to assess safety and immunogenicity of intradermal (ID) DNA priming, intramuscular (IM) MVA and IM rgp140/GLA-AF boosting in healthy volunteers in Tanzania and to develop further HIV vaccine trial capacity building in Tanzania.
TaMoVac II
HIV vaccine trial capacity building in Tanzania and Mozambique by continued exploration of optimal DNA priming and MVA boosting strategies
TAPS
Transfusion Alternatives Pre-operatively in Sickle-cell disease (TAPS) randomised controlled trial
TB-CHAMP
Tuberculosis Child Multidrug-resistant Preventive Therapy Trial
TE04
A prospective study of surveillance in stage 1 non-seminomatous testicular tumours
TE05
Adjuvant bleomycin, etoposide and cisplatin (BEP) in the treatment of "high risk" stage I non-seminomatous germ cell tumours
TE08
A randomised trial of two vs five CT scans in the surveillance of patients with stage I non-seminomatous germ cell tumours of the testis
TE09
Randomised trial of carboplatin- vs cisplatin based chemotherapy for good prognosis metastatic non-seminomatous germ cell tumours
TE11
A prospective study of risk factors for carcinoma in situ of the contralateral testis in patients with testicular cancer
TE12
A randomised trial of single agent carboplatin vs etoposide and cisplatin for advanced metastatic seminoma
TE13
A randomised trial of BEP (bleomycin, etoposide, cisplatin) vs BOP/VIP-B (bleomycin, vincristine, cisplatin, etoposide, ifosfamide cisplatin, bleomycin) and of the same regimens with or without G-CSF in poor prognosis metastatic germ cell tumours
TE14
Prognostic factors for patients with advanced seminoma treated with platinum based chemotherapy
TE15
Prognostic factors in patients progressing after platinum-based chemotherapy for metastatic non-seminomatous germ cell tumours
TE16
Post chemotherapy residual masses in germ cell tumour patients
TE17
Adjuvant bleomycin, vincristine and cisplatin for high-risk stage I non-seminomatous germ cell tumours
TE20
A randomised trial of 3 cycles of BEP versus 3 cycles of BEP plus 1 cycle of EP and the 3-day versus the 5-day schedule in good prognosis metastatic germ cell cancer
TE21 (EORTC 30983)
A randomised trial of BEP vs Taxol-BEP in histologically proven metastatic germ cell cancer with intermediate prognosis
TE23
A randomised phase II trial of intensive induction chemotherapy (CBOP/B15EP) and standard BEP chemotherapy in poor prognosis male germ cell tumours
TICO/ACTIV-3/INSIGHT-014
Does giving patients hospitalised with COVID-19 a synthetically made antibody that blocks the virus make them get better more quickly?
TIME1
The first therapeutic intervention in malignant pleural effusion trial
TIME2
The second therapeutic intervention in malignant effusion trial
TIME3
A randomised controlled trial to evaluate whether use of intrapleural urokinase aids the drainage of multi-septated malignant pleural effusion compared to placebo
TOPPS
A Randomised Controlled Trial Of Prophylactic Vs No-Prophylactic Platelet transfusions in Patients with Haematological malignancies
Top-Up
Microbicides Development Programme Top-Up study
TRACT
Transfusion and Treatment of severe Anaemia in African Children: a randomised controlled Trial
TRANSORCE
A study to collect blood and tissue samples from consenting patients who have been diagnosed with kidney cancer
TRISST (MRC TE24)
Trial of imaging and schedule in seminoma testis
TRUNCATE-TB
Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for drug-sensitive Tuberculosis
UK Inject
Randomised controlled trial to assess the feasibility of the UK Inject trial: a trial comparing oral versus injectable methadone in the treatment of opoid dependent injecting drug users
UKHVC_003
A Phase I clinical trial investigating immunisation strategies using DNA, MVA and CN54rgp140 adjuvanted with GLA-AF to maximise antibody responses.
UKR
UK Register of HIV seroconverters
UKCTOCS
UK Collaborative Trial of Ovarian Cancer Screening
UKLWC
UKCTOCS Longitudinal Women’s Cohort
UKOPS
UK Ovarian Cancer Population Study
V001
A phase I randomised trial to evaluate the safety and immunogenicity of a recombinant human immunodeficiency virus envelope preparation (rgp120) with novel potent adjuvants
VIDEO
Vitamin D evaluation in osteoarthritis
VIETNARMS
A strategic post-licensing trial of oral direct acting antiviral Hepatitis C treatment in VIETNam incorporating a novel design with multiple ARMS
VERDI
SARS-CoV2 Variants Evaluation in Pregnancy and Paediatrics Cohorts