Which standard of care antibiotic intervention is the most effective?

Staphylococcus aureus Network Adaptive Platform

What is this study about?

When bacteria are multiplying in the blood, this is called a bloodstream infection or bacteraemia. Bloodstream infections are a common problem and can be very serious and even life-threatening. They can be caused by different bacteria, but one of the common is a bacteria called Staphylococcus aureus (also known as aureus). S. aureus can cause infection anywhere in the body, including ‘deep’ infections in the bones or inside the heart.

S.aureus bloodstream infections are common, and there are lots of different antibiotics that can be used to treat it and work. However; we still don’t know which of these antibiotics are best, or how long to give them through a vein (intravenous, IV) or by mouth (oral).

SNAP is a large international clinical research study where different treatments will be compared to see which is best for patients.

Type of study

Randomised trial

Contact details

Who is funding the study?

SNAP is funded by the National Institute for Health and Care Research (NIHR).

When is it taking place?

The trial opened in the UK in November 2023 and is expected to run until 2027.

Where is it taking place?

UK, Australia, New Zealand, Canada, Singapore, Israel, South Africa and The Netherlands.

Who is included?

To join SNAP, participants need to be in hospital, with a blood infection caused by S. aureus.