A phase II study of Adriamycin and cisplatin in spindle cell sarcoma of bone other than osteosarcoma

Can chemotherapy help people with a rare type of bone cancer?

What was this study about?

Spindle cell sarcomas are a rare type of bone cancer. Small research studies had suggested that chemotherapy could be used to treat people with this type of bone cancer, thus helping them to live longer.

The BO05 trial aimed to test whether two chemotherapy drugs, cisplatin and doxorubicin, could be used to help treat people with spindle cell sarcoma.

What difference did this study make?

This trial suggested that these chemotherapy drugs could help people with spindle cell sarcoma to live longer.

As a result of this trial, chemotherapy has become the usual treatment for people with this type of bone cancer.

Type of study

Randomised trial

Contact details

Who funded the study?

The Medical Research Council.

When did it take place?

This trial recruited patients between 1988 and 1996. The results were published in 1999.

Who was included?

108 patients with spindle cell sarcoma were recruited to this study.