All Studies

Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data

Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trials

Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data

The bullous pemphigoid steroids and tetracyclines study

Big Lung Trial: A randomised trial to determine the value of cisplatin-based chemotherapy for all patients with non-small cell lung cancer

Two adjuvant chemotherapy regimens in the treatment of osteosarcoma

A randomised pilot study of two drug combinations in patients with osteosarcoma

A randomised trial of two-drug versus multi-drug chemotherapy in the treatment of operable osteosarcoma

A phase II study of cisplatin, ifosfamide and doxorubicin (PIA) chemotherapy in operable primary, axial skeletal and metastatic osteosarcoma

A phase II study of Adriamycin and cisplatin in spindle cell sarcoma of bone other than osteosarcoma

A randomised trial of chemotherapy with or without granulocyte colony stimulating factor (G-CSF) in operable osteosarcoma

Medical Research Council Study of Misonidazole in Conjunction with Radiotherapy for the Treatment of Malignant Gliomas (Astrocytomas) Grades III and IV

A Medical Research Council Study of Two Radiotherapy Dose Regimens for the Treatment of Adult Patients with Malignant Gliomas Grades III and IV

A study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytomas

Randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC 22845 randomised trial

A randomised trial of adjuvant chemotherapy in high grade malignant glioma

Temozolomide versus PCV chemotherapy in the treatment of recurrent malignant glioma

Primary chemotherapy with temozolomide vs. radiotherapy in patients with low grade glioma after stratification for genetic 1p loss: a phase III study. Intergroup Study (EORTC 22033-26033)

Phase III trial on concurrent and adjuvant temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma. The CATNON Intergroup trial

Short-Cycle Therapy (SCT) (5 days on/2 days off) in young people with chronic HIV infection

A randomised open label two-arm, 96 week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir based triple ART in virologically suppressed HIV infected adolescents aged 12 to 19 years of age in sub Saharan Africa

A randomised placebo controlled trial of a cholinesterase inhibitor in the management of agitation in dementia that is unresponsive to a psychological intervention

Cannabis in multiple sclerosis: a randomised, double blind, placebo controlled trial

Autologous stem cell transplantation for malignancy: a systematic review of the literature

A randomised clinical trial as proof of principle of the analgesic effectiveness of cannabinoids on post-operative pain

An open label study: would a single oral dose of a cannabis plant extract (Cannador) help to provide pain relief after surgery.

An open phase I trial of 13% cellulose acetate phthalate vaginal microbicide with randomisation to an observation control

Efficacy, safety and impact on antimicrobial resistance of duration and dose of amoxicillin treatment for young children with Community-Acquired Pneumonia (CAP): a randomised controlled trial

Concerted action on seroconversion to AIDS and death in Europe

An International Prospective Observational Study to Assess the Characteristics and Outcomes of Post-transplant Patients Treated for C. Difficile Infections

Concomitant chemoradiotherapy versus radiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data.

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review

Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review and meta-analysis of individual patient data

Co-trimoxazole as prophylaxis against opportunistic infections in HIV-infected Zambian children: a double-blind randomised placebo-controlled trial

Children with HIV in Africa – Pharmacokinetics and adherence/acceptability of simple antiretroviral regimens

Children with HIV in Africa – Pharmacokinetics and Acceptability of Simple second-line antiretroviral regimens

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy

A randomised multicentre trial of continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in head and neck cancer

Children with HIV early antiretroviral therapy

Collaborative HIV Paediatric Study

Optimising the health of young people with HIV in their transition from paediatric to adult care

A large phase III multi-centre randomised trial to determine the impact of timing of surgery and chemotherapy in newly diagnosed patients with advanced epithelial ovarian, primary peritoneal or fallopian tube cancer

A three arm randomised controlled trial comparing either continuous chemotherapy plus cetuximab, or intermittent chemotherapy with standard continuous palliative combination chemotherapy with oxaliplatin and a fluoropyrimidine in first line treatment of metastatic colorectal cancer

A two-arm phase II randomised trial of intermittent chemotherapy plus continuous cetuximab and of intermittent chemotherapy plus intermittent cetuximab in first line treatment of patients with K-ras-normal (wild-type) metastatic colorectal cancer

Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis

A collaborative initiative to describe the neurological features of COVID-19

Developing a Core Outcome Set for trials in the treatment of severe malaria

A first-in-human clinical trial to assess the safety and immunogenicity of a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID 19

Drug treatment for bowel cancer: making the best choices when a milder treatment is needed

A Phase I clinical trial to assess the safety and immunogenicity of three HIV GTU® MultiHIV DNA immunisations administered via the Intramuscular, Intradermal and Transcutaneous routes in healthy male and female volunteers.

A Phase I clinical trial to assess the safety and immunogenicity of HIV DNA-C CN54ENV immunisations administered via the Intramuscular and Intradermal methods with and without electroporation followed by boosting with recombinant HIV CN54gp140 in healthy male and female volunteers.

A randomized phase I/II study to assess the safety and immunogenicity of the DNA-GTU vaccine administered by two novel methods compared to placebo in HIV-infected patients on antiretroviral therapy

Development of AntiRetroviral Therapy in Africa - A randomised trial of monitoring practice and structured treatment interruptions in the management of antiretroviral therapy in adults with HIV infection in Africa

Donepezil and memantine in moderate to severe Alzheimer’s disease

A Duel centre dose-Ranging trial of Emmelle (dextrin sulphate) gel in preparation for an African Microbicide trial

A randomised non-inferiority trial with nested PK to assess DTG/3TC fixed dose formulations for the maintenance of virological suppression in children with HIV infection aged 2 to <15 years old

Duration of androgen suppression with post-operative radiotherapy (DADSPORT): A meta-analysis of aggregate data

Europe-Africa Research Network for Evaluation of Second-line Therapy

Epidemiology and survival of transfusion recipients

A phase I, prophylactic HIV vaccine trial to evaluate the safety and immunogenicity of HIV Clade C DREP alone and in combination with a Clade C ENV protein in healthy HIV-uninfected adults

A Phase I/II randomised therapeutic HIV vaccine trial in individuals who started antiretrovirals during primary or chronic infection

A Phase II randomised, placebo-controlled trial of vedolizumab with or without therapeutic HIV MVA vaccine in individuals who started antiretrovirals during primary or chronic infection

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma

European Pregnancy and Paediatric Infections Cohort Collaboration

A randomised trial of the European and American Osteosarcoma Study group to optimize treatment strategies for resectable osteosarcoma based on the histological response to pre-operative chemotherapy

A trial to compare the immune responses and safety of two versus three DNA HIV vaccine primes in combination regimens with a pox vector boost in healthy volunteers

Evaluation of the NYVAC C vaccine in HIV-negative individuals

A phase I trial to assess the safety of 4 ml DNA C (intramuscular [IM]), and the safety and immunogenicity of DNA C followed by NYVAC C (IM) in an open, randomised comparison to NYVAC C alone in healthy volunteers at low risk of human immunodeficiency virus (HIV) infection

Fluid Expansion As Supportive Therapy in critically ill African children.

An International Observational Study to Characterize Adults with Influenza or Other Targeted Respiratory Viruses

An international observational study to characterise adults who are hospitalised with influenza or other targeted respiratory viruses

Anti-Influenza Hyperimmune Intravenous Immunoglobulin Clinical Outcome Study

A study to determine the feasibility of molecular selection of therapy using KRAS, BRAF and topo-1 in patients with metastatic or locally advanced colorectal cancer

A molecularly-stratified randomised controlled trial programme for patients with advanced colorectal (bowel) cancer

An open, randomised trial to evaluate the activity and tolerability of combinations of reverse transcriptase and protease inhibitors, including induction therapy, in individuals with HIV-1 infection and CD4 counts greater than 25 x 106/L

Gastroenteritis Aggressive Versus Slow Treatment for Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO Plan C versus slower rehydration.

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial

Granulocytes in Neutropenia clinical study

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

Evaluation of the efficacy of hydroxychloroquine in decreasing immune activation in asymptomatic HIV-infected patients

UK HIV Drug Resistance Database

Trial of HLA epitope matched platelet transfusion in aplastic anaemia and MDS patients

Partnership to cure hepatitis C virus (HCV) in mono- and HIV/HCV co-infected pregnant women and prevent VERTical HCV transmission.

Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden

A two-centre, randomised, double-blinded phase I study to evaluate the safety and immunogenicity of 2 doses of candidate HIV-1 Clade A DN/A vaccine or placebo followed by a candidate HIV-1 Clade A MVA vaccine or placebo in healthy volunteers at low risk of HIV infections

A double-blind, placebo-controlled, three arm randomised multi-centre GCIG trial of AZD2171 in patients with ovarian cancer

Chemotherapy with or without bevacizumab for ovarian cancer, primary peritoneal cancer or fallopian tube cancer

An international phase III randomised trial of dose fractionated chemotherapy compared to standard three weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer

A phase 3 randomised trial investigating the combination of dose-fractionated chemotherapy and bevacizumab compared to either strategy alone for the first-line treatment of women with newly diagnosed high-risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer

Induction chemotherapy and CHART in non-small cell lung cancer

An open randomised trial to evaluate different therapeutic strategies of combination therapy for HIV-1 infection

An International Multicenter, Adaptive, Randomized Double-Blind, Placebo-Controlled Trial of the Safety, Tolerability and Efficacy of Anti-Coronavirus Hyperimmune Intravenous Immunoglobulin for the Treatment of Adult Hospitalized Patients at Onset of Clinical Progression of COVID-19

An International Observational Study of Outpatients with SARS-CoV-2 Infection

A Kaletra ONCE daily Randomised Trial of the pharmacokinetics, safety and efficacy of twice-daily versus once-daily lopinavir/ritonavir tablets dosed by weight as part of combination antiretroviral therapy in HIV-1 infected children.

Kawasaki Disease Coronary Artery Aneurysm Prevention trial

Optimising clinical care strategies and laboratory monitoring for cost-effective roll-out of antiretroviral therapy in Africa: the Lablite project

Long-Acting Treatment in Adolescents (LATA): A randomised, open-label, two-arm, 96 week trial in virologically suppressed HIV-1-positive adolescents aged 12-19 years of age in sub-Saharan Africa

Four-layer compression bandage compared with short stretch bandage for venous leg ulcers: A systematic review and meta-analysis of randomised controlled trials of individual patient data

Three versus six courses of etoposide, cyclophosphamide, methotrexate and voncristine versus six courses of etoposide and ifosfamide in small cell lung cancer

A phase II trial of alternating chemotherapy and radiotherapy in small cell lung cancer

A randomised trial of post-operative radiotherapy in non-small cell lung cancer

A randomised trial of 4-drug vs less intensive 2-drug chemotherapy in the palliative treatment of patients with non-small cell lung cancer and a poor prognosis

A randomised trial of palliative 2-fraction vs more intensive 13-fraction radiotherapy for patients with inoperable NSCLC and a good performance status

Adding GCSF (lenograstim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

Adding GCSF (filgrastim) to chemotherapy to try and increase the dose intensity of chemotherapy given to patients with small cell lung cancer

A randomised trial of oral etoposide vs intravenous multi-drug chemotherapy in the palliative treatment of patients with small cell lung cancer and a poor prognosis

A randomised trial of supportive treatment with or without immediate thoracic radiotherapy in the prevention and palliation of symptoms in patients with inoperable non-small cell lung cancer and minimal thoracic symptoms

A randomised controlled clinical trial of endobronchial treatment versus external beam radiotherapy in the management of endotracheal or endobronchial obstruction by lung cancer

A randomised controlled intensification clinical trial of chemotherapy with or without recombinant human granulocyte colony stimulating factor (G-CSF) in small-cell lung cancer

A randomised trial of neo-adjuvant chemotherapy followed by resection versus radiotherapy in patients with T3, N1, M0 or T1-3, N2, M0 non-small cell lung cancer (NSCLC)

A randomised clinical trial of isosfamide, carboplatin and etoposide with mid-cycle vincristine (ICE-V) versus standard practice chemotherapy in patient with small-cell lung cancer (SCLC) and good performance status

Surgical resection with or without pre-operative chemotherapy in patients with operable non-small cell lung cancer

Preoperative chemotherapy for non-small cell lung cancer: a systematic review and meta-analysis of individual participant data

Adjuvant chemotherapy and surgery (with or without radiotherapy) versus surgery (with or without radiotherapy) for non-small cell lung cancer: Two systematic reviews and meta-analyses of individual patient data

Chemotherapy and supportive care versus supportive care for advanced non-small cell lung cancer: A systematic review and meta-analysis of individual patient data

Should tyrosine kinase inhibitors be considered for advanced non-small cell lung cancer with wild type EGFR? Two systematic reviews and meta-analyses of randomised trials

Postoperative radiotherapy for non‐small cell lung cancer

A multicentre evaluation of National Cancer Institute protocol 89-C-41 (with minor modifications) in Burkitt or Burkitt-like non-Hodgkin lymphoma

A randomised trial of therapy for advanced Hodgkin lymphoma

A multicentre, 48 week randomised controlled factorial trial of adding maraviroc and/or metformin for hepatic steatosis in HIV-1-infected adults on combination antiretroviral therapy.

A phase III trial to test the effectiveness of PRO2000/5

A randomised trial of active symptom control with or without chemotherapy in patients with malignant pleural mesothelioma

A randomised, vaginal microbicide trial to assess the safety of dextrin sulphate gel versus vehicle placebo in Uganda

A randomised, placebo controlled, vaginal microbicide trial assessing the safety of PRO 2000/5 Gel (P) versus vehicle placebo in Uganda

A randomised, double blind, placebo controlled study to assess the efficacy and safety of intra-pleural streptokinase in pleural empyema

Second Multi-centre Intra-pleural Sepsis Trial

Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular trial

A Phase I clinical trial to assess the safety and immunogenicity of three HIV CN54gp140 immunisations administered through the intramuscular, intranasal and intravaginal routes in healthy female volunteers

Prison-based Naloxone-on-release pilot randomised controlled trial investigating the first 10% of a larger trial to reduce drugs-related deaths soon after release

Efficacy and safety of whole-body chlorhexidine gluconate (CHG) cleansing in reducing bacterial skin colonisation of hospitalised neonates: A pilot trial

An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase

Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis

Optimal Clinical Trials Platform for Progressive Multiple Sclerosis

A randomised trial of dolutegravir-based antiretroviral therapy vs. standard of care in children with HIV infection starting first-line or switching to second-line antiretroviral therapy.

Randomised controlled clinical trial of surgery with or without pre-operative chemotherapy in the treatment of respectable cancer of the oesophagus

A randomised controlled trial comparing standard chemotherapy followed by resection versus ECX chemotherapy followed by resection in patients with resectable adenocarcinoma of the oesophagus

Preoperative radiotherapy for oesophageal carcinoma: systematic review and meta-analysis of individual patient data

Early treatment based on CA125 levels alone versus delayed treatment based on conventional clinical indicators

Phase III study of Erlotinib vs. observation in ovarian cancer

Platform Assessing Regimens And Durations In a Global Multisite consortium for TB: A seamless Phase 2B/2C platform trial to evaluate multiple regimens and durations of treatment in pulmonary tuberculosis)

A randomised controlled trial of transcutaneous oestrogen patches versus LHRH agonists in prostate cancer

Prophylactic Antibiotics for the Treatment of Cellulitis at Home

A randomised trial of prophylactic cranial irradiation in patients with limited disease SCLC and a complete response after induction therapy

Impact of oral step-down to amoxicillin or co-amoxiclav and of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in severe childhood community-acquired pneumonia (CAP): a randomised controlled trial

Can the dose of the polymyxin B antibiotic be optimised to be used in babies, children and adolescents?

A phase II/III randomised, open-label study of combination antiretroviral regimens and treatment-switching strategies in HIV-1 infected antiretroviral naïve children >30 days and <18 years of age.

Treatment interruption in children with chronic HIV-infection

Plasma pharmacokinetic study of once versus twice daily abacavir as part of combination antiretroviral therapy in children with human immunodeficiency virus-1 infection aged 3 months to <36 months

A randomised trial to evaluate the usefulness of resistance testing in the clinical management of children with HIV infection.

Protease Inhibitor monotherapy Versus Ongoing Triple-therapy in the long-term management of HIV infection

Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial

A randomised trial of oral sodium clodronate versus a matching placebo in patients with locally advanced prostatic adenocarcinoma

A randomised trial of oral sodium clodronate versus a matching placebo in patients with metastatic prostate adenocarcinoma.

Radical prostatectomy vs radical radiotherapy vs no immediate treatment for localised prostate cancer: a randomised controlled trial

A randomised trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer

PREliminary development of a Multi-Arm, multi-Stage Trial platfOrm for Dementia & mild cOgNitive impairment due to Alzheimer's Disease (PRE-MASTODON-AD)

A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome

A Phase IIb three-arm, two-stage HIV prophylactic vaccine trial with a second randomisation to compare TAF/FTC to TDF/FTC as pre-exposure prophylaxis.

Systematic review of therapeutic interventions in human prion disease

Partially randomised trial of quinacrine in human prion disease

Trial of Prion-filtered vs Standard Red cells in Surgical and Multi-transfused Patients

A multi-centre randomised controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor (GM-CSF) to reduce sepsis in pre-term infants

Prostate MRI Imaging Study - Evaluation of multi-parametric magnetic imaging in the diagnosis and characterisation of prostate cancer

PRe-exposure Option for reducing HIV in the UK: an open-label randomisation to immediate or deferred daily Truvada for HIV negative gay men

Quality of life after treatment of brain metastases

Radiotherapy and androgen deprivation in combination after local surgery. A randomised controlled trial in prostate cancer

Renal Adjuvant MultiPle Arm Randomised Trial: An international investigator-led phase III multi arm multi stage multi-centre randomised controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse

A randomised controlled trial of Interferon-a, Interleukin-2 and 5-Fluorouracil vs Interferon-a alone in patients with advanced renal cell carcinoma

Reduction of EArly mortaLITY in HIV-infected adults and children starting antiretroviral therapy

REduced Frequency ImmuNE checkpoint inhibition in cancers

Controlled comparison of two moxifloxacin containing treatment shortening regimens in pulmonary tuberculosis

An international multicentre controlled clinical trial to evaluate high dose rifapentine and a quinolone in the treatment of pulmonary tuberculosis

Research In Viral Eradication of HIV Reservoirs

A randomised controlled trial of high dose versus standard dose conformal radiotherapy for localised prostate cancer

Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Treatment

Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Diagnostics

Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual participant data

SELPHI: An HIV Self-testing Public Health Intervention

A phase II double-blind, placebo controlled, randomised, single centre study to assess the safety, tolerability and acceptability of dextrin-2-sulphate (DS) gel in sexually active female subjects and their male sexual partners at low risk of HIV infection

A randomised trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses/fixed-dose-combination drugs in African and Indian HIV+ and HIV- children

Evaluating the efficacy, safety and tolerability of a novel and potentially shorter drug regimen (BPaMZ) for patients with drug-sensitive (DS) and drug-resistant (MDR-) pulmonary tuberculosis

Severe Malaria - A Research and Trials consortium

A large, simple trial comparing two strategies for management of anti-retroviral therapy

Strategy for Maintenance of HIV suppression with once daily integrase inhibitor +darunavir/ritonavir in children

Which standard of care antibiotic intervention is the most effective?

A multi-centre phase III double-blind placebo-controlled study designed to examine the efficacy and tolerability of sorafenib (Nexavar) in patients with resected (total or partial) primary renal cell carcinoma (RCC) at high or intermediate risk of relapse

Short Pulse Anti-Retroviral Therapy At sero-Conversion

A randomised, controlled trial of pre- and post-operative chemotherapy in patients with operable gastric and lower oesophageal cancer

A randomised phase II/III trial of perioperative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma and a feasibility study evaluating lapatinib in HER-2 positive oesophagogastric adenocarcinomas and (in selected centres) MRI and PET/CT sub-studies

Systemic Therapy in Advancing or Metastatic Prostate cancer: Evaluation of Drug Efficacy

Shorter Treatment for Advancing Novel Drugs

Strategic Timing of AntiRetroviral Treatment

Stratified Treatment Optimisation for HCV-1

Addition of bisphosphonates to standard of care in men with localised, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of docetaxel to standard of care in men with localised hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Speeding up the evaluation of therapies for metastatic, hormone-sensitive prostate cancer

Addition of abiraterone to standard of care in men with metastatic hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

What is the optimal systemic treatment of men with metastatic, hormone-sensitive prostate cancer? a systematic review and network meta-analyses of aggregate data

Addition of bisphosphonates to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of docetaxel to standard of care in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

Addition of prostate radiotherapy to ADT in men with metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

The evaluation of a standardised treatment regimen of anti-tuberculosis drugs for patients with MDR-TB

The Evaluation of a Standardised Treatment Regimen of Anti-Tuberculosis Drugs for Patients with MDR-TB

Strategies and Treatments for Respiratory Infections & Viral Emergencies

A randomised international multi-centre trial for the evaluation of a four-drug fixed dose combined tablet daily in the initial phase (2 months) of chemotherapy followed by a two-drug fixed dose combined tablet three times a week in the continuation phase (4 months) for the treatment of pulmonary tuberculosis.

A randomised trial of 6 months intensified anti-tuberculosis and 2 months anti-inflammatory treatment for HIV-infected and HIV-uninfected African and Asian children with tuberculous meningitis

Softened Water Eczema Trial

Studying Treatments in patients receiving androgen deprivation therapy (ADT) and androgen receptor signalling inhibitors (ARSI) for Metastatic Prostate Cancer: Evaluation of Drug and radiation Efficacy: A 2nd multi-arm multi-stage randomised controlled trial (STAMPEDE2).

Severe neonatal infection adaptive platform trials in Africa

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children

A Phase I/II trial to assess safety and immunogenicity of intradermal (ID) DNA priming, intramuscular (IM) MVA and IM rgp140/GLA-AF boosting in healthy volunteers in Tanzania and to develop further HIV vaccine trial capacity building in Tanzania.

HIV vaccine trial capacity building in Tanzania and Mozambique by continued exploration of optimal DNA priming and MVA boosting strategies

Transfusion Alternatives Pre-operatively in Sickle-cell disease (TAPS) randomised controlled trial

Tuberculosis Child Multidrug-resistant Preventive Therapy Trial

A prospective study of surveillance in stage 1 non-seminomatous testicular tumours

Adjuvant bleomycin, etoposide and cisplatin (BEP) in the treatment of "high risk" stage I non-seminomatous germ cell tumours

A randomised trial of two vs five CT scans in the surveillance of patients with stage I non-seminomatous germ cell tumours of the testis

Randomised trial of carboplatin- vs cisplatin based chemotherapy for good prognosis metastatic non-seminomatous germ cell tumours

A prospective study of risk factors for carcinoma in situ of the contralateral testis in patients with testicular cancer

A randomised trial of single agent carboplatin vs etoposide and cisplatin for advanced metastatic seminoma

A randomised trial of BEP (bleomycin, etoposide, cisplatin) vs BOP/VIP-B (bleomycin, vincristine, cisplatin, etoposide, ifosfamide cisplatin, bleomycin) and of the same regimens with or without G-CSF in poor prognosis metastatic germ cell tumours

Prognostic factors for patients with advanced seminoma treated with platinum based chemotherapy

Prognostic factors in patients progressing after platinum-based chemotherapy for metastatic non-seminomatous germ cell tumours

Post chemotherapy residual masses in germ cell tumour patients

Adjuvant bleomycin, vincristine and cisplatin for high-risk stage I non-seminomatous germ cell tumours

A randomised trial of 3 cycles of BEP versus 3 cycles of BEP plus 1 cycle of EP and the 3-day versus the 5-day schedule in good prognosis metastatic germ cell cancer

A randomised trial of BEP vs Taxol-BEP in histologically proven metastatic germ cell cancer with intermediate prognosis

A randomised phase II trial of intensive induction chemotherapy (CBOP/B15EP) and standard BEP chemotherapy in poor prognosis male germ cell tumours

Does giving patients hospitalised with COVID-19 a synthetically made antibody that blocks the virus make them get better more quickly?

The first therapeutic intervention in malignant pleural effusion trial

The second therapeutic intervention in malignant effusion trial

A randomised controlled trial to evaluate whether use of intrapleural urokinase aids the drainage of multi-septated malignant pleural effusion compared to placebo

A Randomised Controlled Trial Of Prophylactic Vs No-Prophylactic Platelet transfusions in Patients with Haematological malignancies

Microbicides Development Programme Top-Up study

Transfusion and Treatment of severe Anaemia in African Children: a randomised controlled Trial

A study to collect blood and tissue samples from consenting patients who have been diagnosed with kidney cancer

Trial of imaging and schedule in seminoma testis

Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for drug-sensitive Tuberculosis

Randomised controlled trial to assess the feasibility of the UK Inject trial: a trial comparing oral versus injectable methadone in the treatment of opoid dependent injecting drug users

A Phase I clinical trial investigating immunisation strategies using DNA, MVA and CN54rgp140 adjuvanted with GLA-AF to maximise antibody responses.

UK Register of HIV seroconverters

UK Collaborative Trial of Ovarian Cancer Screening

UKCTOCS Longitudinal Women’s Cohort

UK Ovarian Cancer Population Study

A phase I randomised trial to evaluate the safety and immunogenicity of a recombinant human immunodeficiency virus envelope preparation (rgp120) with novel potent adjuvants

Vitamin D evaluation in osteoarthritis

A strategic post-licensing trial of oral direct acting antiviral Hepatitis C treatment in VIETNam incorporating a novel design with multiple ARMS

SARS-CoV2 Variants Evaluation in Pregnancy and Paediatrics Cohorts

Shortening and simplifying treatment for hard to treat forms of TB