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Platform Assessing Regimens And Durations In a Global Multisite consortium for TB: A seamless Phase 2B/2C platform trial to evaluate multiple regimens and durations of treatment in pulmonary tuberculosis)

A randomised controlled trial of transcutaneous oestrogen patches versus LHRH agonists in prostate cancer

Prophylactic Antibiotics for the Treatment of Cellulitis at Home

A randomised trial of prophylactic cranial irradiation in patients with limited disease SCLC and a complete response after induction therapy

Impact of oral step-down to amoxicillin or co-amoxiclav and of duration of antibiotic therapy on effectiveness, safety and selection of antibiotic resistance in severe childhood community-acquired pneumonia (CAP): a randomised controlled trial

Can the dose of the polymyxin B antibiotic be optimised to be used in babies, children and adolescents?

A phase II/III randomised, open-label study of combination antiretroviral regimens and treatment-switching strategies in HIV-1 infected antiretroviral naïve children >30 days and <18 years of age.

Treatment interruption in children with chronic HIV-infection

Plasma pharmacokinetic study of once versus twice daily abacavir as part of combination antiretroviral therapy in children with human immunodeficiency virus-1 infection aged 3 months to <36 months

A randomised trial to evaluate the usefulness of resistance testing in the clinical management of children with HIV infection.

Protease Inhibitor monotherapy Versus Ongoing Triple-therapy in the long-term management of HIV infection

Platelet Process Improvement Project - Comparison of platelets stored for 2-5 days versus platelets stored for 6-7 days in preventing and treating haemorrhage in thrombocytopenic patients – a randomised controlled trial

A randomised trial of oral sodium clodronate versus a matching placebo in patients with locally advanced prostatic adenocarcinoma

A randomised trial of oral sodium clodronate versus a matching placebo in patients with metastatic prostate adenocarcinoma.

Radical prostatectomy vs radical radiotherapy vs no immediate treatment for localised prostate cancer: a randomised controlled trial

A randomised trial of hormone therapy plus radical radiotherapy versus hormone therapy alone in non-metastatic prostate cancer

PREliminary development of a Multi-Arm, multi-Stage Trial platfOrm for Dementia & mild cOgNitive impairment due to Alzheimer's Disease (PRE-MASTODON-AD)

A randomised controlled trial of continuous positive airway pressure treatment in older people with obstructive sleep apnoea/hypopnoea syndrome

A Phase IIb three-arm, two-stage HIV prophylactic vaccine trial with a second randomisation to compare TAF/FTC to TDF/FTC as pre-exposure prophylaxis.

Systematic review of therapeutic interventions in human prion disease

Partially randomised trial of quinacrine in human prion disease

Trial of Prion-filtered vs Standard Red cells in Surgical and Multi-transfused Patients

A multi-centre randomised controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor (GM-CSF) to reduce sepsis in pre-term infants

Prostate MRI Imaging Study - Evaluation of multi-parametric magnetic imaging in the diagnosis and characterisation of prostate cancer

PRe-exposure Option for reducing HIV in the UK: an open-label randomisation to immediate or deferred daily Truvada for HIV negative gay men