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FAME, our new framework for prospective, adaptive meta-analysis (FAME), can help produce more timely, thorough, and reliable systematic reviews of aggregate data.
A large-scale randomised trial of annual screening for ovarian cancer did not succeed in reducing deaths from the disease, despite one of the screening methods tested detecting cancers earlier.
A new consensus algorithm that could save the lives of children with severe anaemia in sub-Saharan Africa has been published in the British Journal of Haematology.

The mega-trial now named OCTOPUS will be delivered by Professors Jeremy Chataway (Chief Investigator, UCL Queen Square Institute of Neurology) and Mahesh Parmar (Director of the MRC Clinical Trials Unit, Faculty of Population Health Sciences) alongside the UK MS society. After a number of years of planning, the ambition to speed up clinical trials for progressive MS has become ...

The anti-HIV drug Dolutegravir improves outcomes for children with HIV infection, when given in a 3-drug anti-HIV combination. These results come from the ODYSSEY trial which was presented yesterday at the Conference on Retroviruses and Opportunistic Infections. Dolutegravir has a number of potential advantages, including: Few drug-to-drug interactions, making it easier to ...