VERDI

What is this study about?

Variants of concern (VoC) of SARS-CoV-2 raise the possibility of increases in transmissibility, severity and immune system evasion. There is less evidence of the effect and impact of VoC on children and pregnant women, who have not been prioritised in the pandemic, compared to non-pregnant adults. Vaccine coverage is often lower in these groups, and there are fewer treatment options.

The 2022-23 mpox outbreak remains unpredictable and it is important to continue to monitor its effects in groups who are currently at higher risk of infection as well as other groups who may be more affected in future.

VERDI (SARS-CoV-2 variants Evaluation in pRegnancy and paeDIatrics cohorts) will investigate the impact of VoC in these vulnerable groups, bringing together 29 centres of excellence from around the world to investigate the emergence, transmission and consequences (morbidity and mortality) of SARS-CoV-2 variants, as well as to understand the epidemiology and impact of mpox in children, pregnant women and high-risk groups.

VERDI’s objectives are to:

1. Track and characterise VoC and mpox in paediatric and pregnant populations and other high risk populations across the globe;
2. Understand effects of VoC and mpox on clinical outcomes (short/longer term), vaccine effectiveness and transmission characteristics;
3. Model outcomes and impacts of VoC and mpox;
4. Develop evidence-based recommendations for control of COVID-19 and mpox and other emerging or re-emerging infections.

The study will also promote flexibility to adapt to future emerging infections.

Type of study

Observational study

Contact details

mrcctu.verdi@ucl.ac.uk

Who is funding the study?

This study is funded by the European Union.