STRIDE (STRIVE 002)

What is this study about?

The protocol is designed to facilitate the observational study of a broad array of acute infectious diseases. It is structured with a master protocol and study-specific appendices.

The study may include respiratory infections, infections outside the respiratory tract, established infectious diseases, and emerging/re-emerging infectious diseases.

Participants will be enrolled onto specific projects that use this protocol as an overarching framework. The broadest eligibility criteria and most extensive study procedures that may be used are described in this protocol with an associated informed consent document. Different, more targeted projects may be opened over time focusing on a particular infectious disease and study population. Such projects may have additional eligibility criteria and different project-specific procedures.

This international observational study will collect longitudinal data and biological samples in hospitalised adults with infections with known or emerging pathogens in an international setting.

The key priorities of this observational protocol are to:

• Characterise and compare the clinical course and natural history of acute infections of interest
• Determine the percentage who die or develop other adverse outcomes during or following hospitalization
• Identify host and pathogen risk factors for poor outcomes.
• Perform pathogen diagnostics including mutational evolution
• As part of pandemic preparedness - establish a global network which can pivot to collect clinical and pathogen data in the event of a new infectious disease emergency

Network coordinating the study: An international observational STudy of Respiratory infections & Infectious disease Emergencies (STRIDE)

Type of study

Observational study

Who is funding the study?

The study is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health (USA).