CHAPAS-4 resources and further information

Child taking medication

The CHAPAS-4 trial is working to improve the second-line treatment options for children living with HIV in sub-Saharan Africa. There are growing numbers of children who need (or will need in the future) second-line antiretroviral therapy. Current second-line treatment options for children are not ideal. CHAPAS-4 is investigating new combinations of medicines for children.

Resources

• This one page document gives an overview on what the trial is, and why it is needed
• This slideset explains the trial in more detail, for clinicians
• This two page document explores the implications of the results of the ODYSSEY trial, and roll-out of dolutegravir, for CHAPAS-4

Infographics

These infographics explain the findings from the CHAPAS-4 trial after 96 weeks. These results were presented at the International AIDS Society Conference in July 2023.

• CHAPAS-4 backbone results infographic
• CHAPAS-4 anchor drug results infographic
• Results poster for children

Publications

• Pre-print: CHAPAS-4 trial: second-line anchor drugs for children with HIV in Africa
• Pre-print: Second-line tenofovir alafenamide for children with HIV in Africa
• First Pharmacokinetic Data of Tenofovir Alafenamide Fumarate and Tenofovir With Dolutegravir or Boosted Protease Inhibitors in African Children: A Substudy of the CHAPAS-4 Trial
• Pharmacokinetic Data of Dolutegravir in Second-line Treatment of Children With Human Immunodeficiency Virus: Results From the CHAPAS4 Trial
• Bone mineral density among children living with HIV failing first -line anti-retroviral therapy in Uganda. A sub-study of the CHAPAS 4 trial
• Voluntariness of consent in paediatric HIV clinical trials: a mixed-methods, cross-sectional study of participants in the CHAPAS-4 and ODYSSEY trials in Uganda
• The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff

Impact of previous trials

The team running the CHAPAS-4 trial have run a number of trials that have made a big impact on how children with HIV are treated. This one-page document summarises the difference those trials have made to children living with HIV.

This film explores the impact of previous trials run by the CHAPAS team in improving HIV treatments for children.

Chapas Clinical Trials - Developing HIV baby pills. from MRC Clinical Trials Unit at UCL on Vimeo.