Search Results | MRC Clinical Trials Unit at UCL

'25 at 25': Improving prostate cancer diagnosis

As part of our ‘25 at 25’ series, highlighting 25 achievements of the MRC Clinical Trials Unit at UCL from the last 25 years, we look at how the PROMIS study has improved how prostate cancer is diagno…

'25 at 25': Patient and Public Involvement (PPI)

For almost two decades, the MRC Clinical Trials Unit at UCL has been committed to actively involving patients and the public in all our clinical trials and studies. As part of our ‘25 at 25’ series to…

'25 at 25': OCTOPUS – speeding up new treatments for progressive MS

OCTOPUS is the first ever multi-arm multi-stage (MAMS) clinical trial in multiple sclerosis (MS). As part of our ’25 at 25’ series, we explore how the trial aims to transform the way that new treatmen…

'25 at 25': Individual participant data (IPD) meta-analysis

...ndividual participant data (IPD). As part of our ‘25 at 25’ series to celebrate the Unit’s 25th anniversary, this piece explores how our IPD meta-analyses have influenced the treatment of patients …

'25 at 25': Shortening treatment for tuberculosis

A long road to recovery lies ahead for people diagnosed with tuberculosis (TB). Treatments lasting several months can be tough for patients due to challenging side effects, the burden of daily medicat…

'25 at 25': The PRACTical trial design

As part of the MRC Clinical Trials Unit at UCL’s 25th anniversary celebrations, we highlight the Unit’s role in developing new clinical trial designs to address problems where standard trial designs a…

'25 at 25': Training and capacity strengthening

Capacity strengthening is at the core of our clinical trials and methodology work, aiming to enhance the skills of trial teams we work with across the globe, so they can deliver their own sustainable,…

'25 at 25': Conducting the first large international randomised controlled trial on tuberculosis treatment for children

... children respond to treatment. As part of our '25 at 25' series, we look back at the SHINE trial, which sought to address this evidence gap. This landmark study was the first randomised controll…

'25 at 25': Reducing deaths among people starting HIV treatment with advanced disease

...irst few weeks of treatment. In this part of our ‘25 at 25’ series, we look back at the REALITY trial, which found a way to prevent deaths among people starting HIV treatment with advanced disease.…

'25 at 25': Framework for Adaptive Meta-analysis (FAME) for timely, reliable and thorough results

In the latest in our ‘25 at 25’ series, celebrating 25 years of the MRC Clinical Trials Unit at UCL, we explore FAME – a collaborative approach to prospective meta-analysis of aggregate data, which sp…