FAME Methods
A framework for prospective, adaptive meta-analysis (FAME) of aggregate data from randomised trials.
Tierney et al (2021) PLoS Med;18(5):e1003629
Application of FAME
Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data.
Vale CL, Burdett S et al (2016) Lancet Oncol;17(2):243-56
Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis.
Rydzewska LHM et al (2017) EJC;84:88-101
Prostate radiotherapy for metastatic hormone-sensitive prostate cancer: a STOPCAP systematic review and meta-analysis.
Burdett S et al (2019) Eur Urol;76(1):115-24
Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Vale et al (2020) Lancet; 396(10260):1422-1431
Duration of androgen suppression with post-operative radiotherapy (DADSPORT): a systematic review and meta-analysis of aggregate data (PROSPERO Protocol).
Burdett S et al (2022). PROSPERO: International prospective register of systematic reviews; CRD42022325769
Duration of androgen suppression with post-operative radiotherapy (DADSPORT): A collaborative meta-analysis of aggregate data.
Burdett S et al (2022) Ann Oncol;33(suppl 7): S808-S69
Aspirin after radical therapy for colorectal cancer: a prospective meta-analysis (PROSPERO Protocol).
Burdett S et al (2023) PROSPERO: International prospective register of systematic reviews; CRD42023453156
Other application of FAME principles
Presentation at ICTMC 2024
PS.8B - Evidence synthesis and data re-use
Thursday 3 October
9:00-10:00 Fintry Auditorium
Dr Claire Vale: Involving trialists for better evidence synthesis: Lessons from a case study in COVID-19
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.
WHO Rapid Evidence Appraisal for COVID-19 Therapies working Group (2020) JAMA;324:1330-1341
Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalized patients with COVID-19: A network meta-analysis.
Godolphin et al (2022) PloS one;17(7):e0270668
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) for hospitalised patients with COVID-19: prospective meta-analysis of randomised trials.
Vale C et al (2024) The Lancet Diabetes and Endocrinology;S2213-8587(24)00219-5
If you are interested in learning more about the FAME approach or think you might have a trial or meta-analysis project that would benefit from FAME principles, please contact Professor Jayne Tierney (jayne.tierney@ucl.ac.uk) or Dr Claire Vale (claire.vale@ucl.ac.uk).