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Prevention, treatment simplification and complicated cases.

Our tuberculosis (TB) research looks at:
  • How to prevent TB illness
  • How to simplify treatment of TB that responds to the most common drugs, to make treatment easier for patients and health systems
  • How to treat complicated TB, including drug resistant TB, and TB meningitis

Nix-TB

Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis

PARADIGM4TB (UNITE4TB-01)

Platform Assessing Regimens And Durations In a Global Multisite consortium for TB: A seamless Phase 2B/2C platform trial to evaluate multiple regimens and durations of treatment in pulmonary tuberculosis)

REMoX-TB

Controlled comparison of two moxifloxacin containing treatment shortening regimens in pulmonary tuberculosis

RID-TB: Dx

Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Diagnostics

RID-TB: Treat

Research to Improve the Detection and Treatment of Latent Tuberculosis Infection: Treatment

RIFAQUIN

An international multicentre controlled clinical trial to evaluate high dose rifapentine and a quinolone in the treatment of pulmonary tuberculosis

SHINE

A randomised trial of therapy shortening for minimal tuberculosis with new WHO-recommended doses/fixed-dose-combination drugs in African and Indian HIV+ and HIV- children

SimpliciTB

Evaluating the efficacy, safety and tolerability of a novel and potentially shorter drug regimen (BPaMZ) for patients with drug-sensitive (DS) and drug-resistant (MDR-) pulmonary tuberculosis

STAND

Shorter Treatment for Advancing Novel Drugs

STREAM Stage 1

The evaluation of a standardised treatment regimen of anti-tuberculosis drugs for patients with MDR-TB

STREAM Stage 2

The Evaluation of a Standardised Treatment Regimen of Anti-Tuberculosis Drugs for Patients with MDR-TB

Study C

A randomised international multi-centre trial for the evaluation of a four-drug fixed dose combined tablet daily in the initial phase (2 months) of chemotherapy followed by a two-drug fixed dose combined tablet three times a week in the continuation phase (4 months) for the treatment of pulmonary tuberculosis.

SURE

A randomised trial of 6 months intensified anti-tuberculosis and 2 months anti-inflammatory treatment for HIV-infected and HIV-uninfected African and Asian children with tuberculous meningitis

TB-CHAMP

Tuberculosis Child Multidrug-resistant Preventive Therapy Trial

TRUNCATE-TB

Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for drug-sensitive Tuberculosis

ZeNix

Shortening and simplifying treatment for hard to treat forms of TB