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Improve clinical outcomes and provide an evidence base for future treatment guidelines

In sub-Saharan Africa, the acutely sick child with unclear underlying cause of illness has high risk of death. Our studies aim to develop and test strategic approaches to improve clinical outcomes and provide an evidence base for treatment guidelines for such children.

COSSMaT

Developing a Core Outcome Set for trials in the treatment of severe malaria

FEAST

Fluid Expansion As Supportive Therapy in critically ill African children.

GASTRO

Gastroenteritis Aggressive Versus Slow Treatment for Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO Plan C versus slower rehydration.

GASTROSAM

Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial

H-PRIME

Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden

NeoSep1

An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase

PROGRAMS

A multi-centre randomised controlled trial of prophylactic granulocyte-macrophage colony-stimulating factor (GM-CSF) to reduce sepsis in pre-term infants

SMAART

Severe Malaria - A Research and Trials consortium

SNIP-AFRICA

Severe neonatal infection adaptive platform trials in Africa

TABS-PKPD

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children

TRACT

Transfusion and Treatment of severe Anaemia in African Children: a randomised controlled Trial