Diana Gibb, Professor of Epidemiology

Diana Gibb is a paediatrician and Professor in Epidemiology and Clinical Trials at the Medical Research Council Clinical Trials Unit, University College, London (MRC CTU at UCL). With a career spanning over three decades, she has set up and orchestrated a global network of clinical trials and cohorts in childhood infectious diseases. Her focus started with paediatric HIV infection in Europe, leading early PENTA trials (Paediatric European Network for Treatment of AIDS 1990).

Her work extended from 2000 to coordinating multi-country trials in East and Sub-Saharan Africa, then extending to India and South East Asia. Trials address multiple strategic treatment and prevention questions, initially in paediatric and adult HIV infection, extending to Malaria, Sepsis and pneumonia, and most recently to trials of paediatric Tuberculosis. Driving to increase efficiency, she has embraced wide collaborations with pharmacologists, social scientists, economists and basic scientists to nest substudies within trials; in collaboration with trial methodologists at MRC CTU, novel trial designs address multiple questions in a single trial. She has lead on developing the hub on capacity strengthening in clinical trials on the Global Health Network.

Professor Gibb was a founder member of PENTA and is vice-chair of the PENTA Foundation Board. She has over 500 publications, and has contributed to guidelines/advisory committees/Boards for World Health Organisation, Wellcome Trust and Medical Research Council. She received an honorary doctorate from York University in 2019 and was elected fellow of the UK Academy of Medical Sciences in 2020.

Selected publications

Turkova A, Wills GH, Wobudeya E, Chabala C, Palmer M, Kinikar A, Hissar S, Choo L, Musoke P, Mulenga V, Mave V, Joseph B, LeBeau K, Thomason MJ, Mboizi RB, Kapasa M, van der Zalm MM, Raichur P, Bhavani PK, McIlleron H, Demers AM, Aarnoutse R, Love-Koh J, Seddon JA, Welch SB, Graham SM, Hesseling AC, Gibb DM, Crook AM; SHINE Trial Team. Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children. New Engl Journal of Med. 2022 Mar 10;386(10):911-922. doi: 10.1056/NEJMoa2104535.N PMID: 35263517.

Turkova A, White E, Mujuru HA, Kekitiinwa AR, Kityo CM, Violari A, Lugemwa A, Cressey TR, Musoke P, Variava E, Cotton MF, Archary M, Puthanakit T, Behuhuma O, Kobbe R, Welch SB, Bwakura-Dangarembizi M, Amuge P, Kaudha E, Barlow-Mosha L, Makumbi S, Ramsagar N, Ngampiyaskul C, Musoro G, Atwine L, Liberty A, Musiime V, Bbuye D, Ahimbisibwe GM, Chalermpantmetagul S, Ali S, Sarfati T, Wynne B, Shakeshaft C, Colbers A, Klein N, Bernays S, Saïdi Y, Coelho A, Grossele T, Compagnucci A, Giaquinto C, Rojo P, Ford D, Gibb DM; ODYSSEY Trial Team. Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children. N Engl J Med. 2021 Dec 30;385(27):2531-2543. doi: 10.1056/NEJMoa2108793.

Bielicki JA, Stöhr W, Barratt S, Dunn D, Naufal N, Roland D, Sturgeon K, Finn A, Rodriguez-Ruiz JP, Malhotra-Kumar S, Powell C, Faust SN, Alcock AE, Hall D, Robinson G, Hawcutt DB, Lyttle MD, Gibb DM, Sharland M; PERUKI, GAPRUKI, and the CAP-IT Trial Group. Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial. JAMA 326(17):1713-1724 02 Nov 2021. doi: 10.1001/jama.2021.17843.

Maitland K, Kiguli S, Olupot-Olupot P, Engoru C, Mallewa M, Saramago Goncalves P, Opoka RO, Mpoya A, Alaroker F, Nteziyaremye J, Chagaluka G, Kennedy N, Nabawanuka E, Nakuya M, Namayanja C, Uyoga S, Kyeyune Byabazaire D, M'baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, George EC, Gibb DM, Walker AS; TRACT Group. Immediate Transfusion in African Children with Uncomplicated Severe Anemia.  The New England Journal of Medicine, 01 Aug 2019, 381(5):407-419. DOI: 0.1056/nejmoa1900105 PMID: 31365799 PMCID: PMC7611152.

Hakim JG, Musiime V, Walker AS and Gibb DM. Enhanced prophylaxis with antiretroviral therapy for advanced HIV Infection in Africa. 2017 Jul. N Engl J Med, 377:233-245. doi: 10.1056/NEJMoa1615822. PMID: 28723333.