Babak Choodari-Oskooei, Principal Research Fellow

Babak is a senior statistician interested in clinical trial methodology, with expertise in adaptive and multi-arm multi-stage (MAMS) platform randomised clinical trials. Babak has a PhD in Statistics from UCL's Statistical Sciences Department. He now mainly works in the Design Methodology program. He has been involved in international adaptive trials in renal cancer (RAMPART), surgery (ROSSINI 2), and maternal health (WHO RED) as a senior statistician.

Babak teaches postgraduate courses and leads short courses in advanced and adaptive trial designs at UCL's Institute of Clinical Trials and Methodology.

His areas of expertise include clinical trial methodology, design of adaptive multi-arm multi-stage (MAMS) randomised platform clinical trials, estimation of treatment effects, and analysis of adaptive MAMS clinical trials. He is also involved in developing statistical packages for these novel trial designs and his work also expands into cancer epidemiology, prognostic modelling of risk factors, and clinical prediction models.

Babak is a member of the UK-wide adaptive design working group (ADWG) and the chair and independent statistician on the data monitoring and trial steering committees for several trials.

Selected publications

Choodari-Oskooei, B., Thwin, S. S., Blenkinsop, A., et al. (2023). “Treatment selection in multi-arm multi-stage designs: With application to a postpartum haemorrhage trial”, Clinical Trials 20(1):71-80. doi:10.1177/17407745221136527

Robertson, D. S., Choodari-Oskooei, B., et al. (2023). “Point estimation for adaptive trial designs II: Practical considerations and guidance”, Statistics in Medicine. doi:10.1002/sim.9734

White, I., Choodari-Oskooei, B., Sydes, M. R., (2022). “Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently”,  Clinical Trials. doi:10.1177/17407745221093577 

Choodari-Oskooei, B., Sydes, M.R., Royston, P., Parmar, M.K.B. (2021). “Multi-arm Multi-stage (MAMS) Platform Randomized Clinical Trials.” In: Piantadosi, S., Meinert, C.L. (eds) Principles and Practice of Clinical Trials. Springer, Cham.

Pallmann, P., Bedding, A. W., Choodari-Oskooei, B., et al. (2018). “Adaptive designs in clinical trials: why use them, and how to run and report them” BMC Medicine, 16 (1), 29. doi:10.1186/s12916-018-1017-7

Research Interests

  • Adaptive trial designs
  • Multi-arm multi-stage (MAMS) designs
  • Simulation studies
  • Estimation of treatment effects
  • Stata and SAS

Research Areas