Angela Crook, Professorial Research Fellow

Angela is a medical statistician who has worked in health research for over 3 decades, most recently focusing on tuberculosis treatment shortening trials. She joined the MRC Clinical Trials Unit at UCL in 2007 as the senior statistician for a large HIV prevention trial, MDP301. She currently co-leads the respiratory programme and is the lead statistician for the SURE trial, investigating treatment shortening in children with TB meningitis and the PARADIGM4TB trial, investigating novel shorter regimens for TB within phase 2. She is also co-lead for the design and analysis work package within the UNITE4TB consortium.

Before joining the MRC CTU at UCL, Angela worked in a range of disease areas and settings including cancer, cardiovascular disease, and public health. She has an MSc in medical statistics from the London School of Hygiene and Tropical Medicine and a PhD from Imperial College, London.

Selected publications

Conradie F, Diacon AH, Ngubane N, Howell, P, Everitt, D, Crook AM, et al. Treatment of Highly Drug-Resistant Pulmonary Tuberculosis. The New England journal of medicine 2020; 382(10): 893-902. doi: 10.1056/NEJMoa1901814

Tweed CD, Dawson R, Burger DA, Conradie F, Crook AM, et al. Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial. Lancet Respir Med 2019; 7(12): 1048-58. doi: 10.1016/S2213-2600(19)30366-2.

Crook AM, Turkova A, Musiime V, et al. Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy. BMC medicine 2016; 14: 50. doi: 10.1186/s12916-016-0593-7.

Gillespie SH, Crook AM, McHugh TD, et al. Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis. The New England journal of medicine 2014; 371(17): 1577-87. doi: 10.1056/NEJMoa1407426.

Crook AM, Ford D, Gafos M, et al. Injectable and oral contraceptives and risk of HIV acquisition in women: an analysis of data from the MDP301 trial. Human reproduction 2014; 29(8): 1810-7. doi: 10.1093/humrep/deu113

Research Interests

  • Clinical trials
  • Shortening treatment for TB in adults and children   
  • TB Meningitis in children

Research Areas

UCL Profiles